ABSTRACT
Objective The purpose of this research study is to assess the knowledge of housing characteristics and associated health problems in nursing students of Dow University of Health Sciences [DUHS]. Moreover, nursing students' knowledge about housing condition and public health risks were also analyzed
Methodology The study was conducted at Institute of Nursing, DUHS, Karachi. In 2012, 90 nursing students were asked to participate in this study with their consents. A teaching session was conducted as a part of this study that lasted for two hours. At the end of teaching session students were requested to fill out the questionnaire about their housing condition and health related problems along with a feedback of the session
Results The study highlighted that on average, participants had been living in the same housing for the last one year, with median and inter-quartile range of 12 and 16 months respectively. Twelve participants [13%] mentioned that they had suffered from diarrhea or vomiting during last three months, and 7.6% participants reported that their housing conditions were affecting their respiratory health. A large number of participants [89.1%] and [87.2%] did not find any visible mold in their house/hostel or kitchen respectively. Almost 61% and 80% participants reported about the mechanical ventilation and window in the bathroom respectively
Conclusion Reduction in dampness results in improvement of various health symptoms. House dust mite can be controlled through constant mechanical ventilation. The majority of the participants showed willingness towards such seminars and discussions for their future classes
ABSTRACT
Background: Epilepsy is one of the most common severe disorders of the brain and 50 million people are affected by epilepsy from all over the world. In the central nervous system [CNS] electrolyte homeostasis is crucial for the brain function. Anti-Epileptic Drugs [AEDs] are neither protective nor healing but employed exclusively to control symptoms such as suppression of seizures
Objective: To assess lipid peroxidation and serum electrolyte profile in epileptic patients exposed on anti-epileptic drugs
Methodology: Fifty patients of epilepsy and ten age and sex-matched clinically apparently healthy individuals were eligible for inclusion in the study at Jinnah Hospital Lahore. 5.0 ml blood sample was taken from each individual and subjected to centrifuge at 3000-4000 rpm for 10-15 minutes for the separation of serum. The estimation of anti-oxidative biomarkers [SOD, MDA, GSH and CAT] and serum electrolyte profile [NA+, K+, Ca++ and Mg++] were estimated
Results: The level of MDA in epileptic patients was increased remarkably [7.08 +/- 0.76] as compared to healthy individuals [1.67 +/- 0.19] and statistically significant [0.000<0.05]. Mg++ level was decreased in epileptic patients [1.44 +/- 0.21] as compared to control [1.68 +/- 0.20] and statistically significant [0.003<0.05]. Serum sodium [Na+] level in epileptic patients was increased [1.64 +/- 9.9] as compared to control persons [1.38 +/- 5.97] and statistically significant [0.004<0.05]
Conclusion: A relationship is present between oxidative stress, electrolyte profile and epilepsy. Lipid peroxidation level and sodium and potassium level is significantly elevated in epileptic patients as compared to control persons
ABSTRACT
A multi-centred study was designed to collect dengue epidemiologic data from government and registered private hospitals/clinics and maintained archive of frozen specimens in bio-bank to be used for future dengue epidemic control program, and assess the epidemiology of dengue fever (DF) by evaluating biochemical and oxidative status of patients. ELISA IgM antibodies test was done to confirm DF. From August 2010 to December 2011, 101 confirmed blood samples of DF patients referred to pathology lab of Jinnah Hospital Lahore were subjected to the epidemiologic assessment by evaluating the biochemical and physiological indices and alterations of circulating antioxidants. Clinical features of DF patients and effect of fever on blood components and serum proteins of liver were recorded. The hospital stay in DF, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) showed significant difference. Significant increases in serum alanine amino transferase (ALT) (P=0.000), aspartate amino transferase (AST) (P=0.000), alkaline phosphatase (ALP) (P=0.000), malondialdehyde (MDA) along with significant decreases in total protein (TP) (P=0.000), reduced glutathione (GSH) (P=0.000), superoxide dismutase (SOD), catalase (CAT) (P=0.000), and sialic acid contents (P=0.016) were observed. A positive correlation existed between bound sialic acid levels, liver enzymes and circulating antioxidants (r=0.656, P=0.016). In the present study, alterations of circulating antioxidants in DF suggest that DF might be a metabolic response to an acute, self-limiting tropical viral infection, and a consequence of the viral inflammatory process.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Young Adult , Antioxidants , Metabolism , Biomarkers , Blood , China , Dengue , Classification , Diagnosis , Metabolism , Diagnosis, Differential , Immunoglobulin M , MetabolismABSTRACT
All over the world Hepatitis C virus [HCV] remains to be a main etiological mediator of liver disease. Approximately, 10 million people in Pakistan are diseased with HCV. Pegylated interferon plus ribavirin signifies the gold standard therapy but various side effects may occur. Comparative study. This study was conducted at Jinnah Hospital Lahore from August 2013 to March, 2014. Thirty five patients of hepatitis C virus and Twenty three age and sex-matched clinically apparently healthy individuals were eligible for inclusion in the study at Jinnah Hospital Lahore during the year 2013-2014. 1.0 ml blood sample were taken and subjected to centrifuge at 3000-4000 rpm for 10-15 minutes for the separation of serum. All the analytical work was performed at the Institute of molecular biology and biotechnology [IMBB], and Centre for research in molecular medicine [CRiMM], The University of Lahore-Pakistan. The estimation of AST, ALT, ALP, TP and T.Bilirubin were estimated. The AST level in HCV patients was increases [47.88 +/- 40.49] as compared to the control persons [31.43 +/- 7.31] and statistically significant [0.02<0.05]. Total Protein level in HCV patients was [4.20 +/- 0.61] and in healthy individuals [6.23 +/- 0.51] and statistically significant [0.000<0.05]. MDA level in HCV patients was increases remarkably [8.58 +/- 1.19] and in control persons [1.47 +/- 0.54] and it was statistically significant [0.000<0.05]. There is a relationship between oxidative stress and ALP, ALT, AST and Albumin. The results of the present study confirmed a perfect sketch regarding the circulating biochemical markers and lipid peroxidation [MDA] profile between the studied groups i.e., control and HCV patients with interferon induced Hepatitis C virus infection
ABSTRACT
Diabetes affects a large number of populations worldwide and the prevalence of this disease is rapidly increasing
Despite the availability of allopathic medications for diabetes, traditional remedies are desirable and are currently being investigated. Garlic [Allium sativum] has been reported to have antidiabetic activity. Evidences suggest that garlic has antioxidant, anti-inflammatory and antiglycative properties due to which it plays an important role in preventing diabetes progression and the development of diabetes-related complications. Large scale clinical studies with diabetic patients have been carried out to confirm the usefulness of garlic in the treatment and prevention of this disease. This article briefly reviews on the above stated subjected and the papers have been collected from internet resources including Pubmed, American Journal of Medicine, New England Journal of Medicine, Google Scholar and Journal of Medicinal Plant Research
ABSTRACT
To evaluate the Morbidity, Co-morbidity profile and Disability status among elderly in Civil Hospital Karachi. A Descriptive cross sectional study. The study was conducted at Civil Hospital Karachi from 15 June 2009 to 15 August 2009. Patients aged 60 years and above admitted to selected wards i.e. Medicine, Cardiac medicine, Surgery, Gynecology, E.N.T and Ophthalmology were included except those patients who had psychiatric illnesses, history of trauma and neurological deficits. A questionnaire was designed for assessment of morbidity, co morbidity and disability status of elderly patients. SPSS version 16 was used for data analysis. A total of 220 elderly subjects [60+] were included in the study. Most common morbidities were cerebrovascular accidents [13.6%], chronic liver diseases [7.7%] and hernias [7.7%]. When classified according to organ systems most common disorders were of digestive system [28.6%], nervous system [15%] and malignancies [12.2%]. Hypertension was the most frequent co-morbidity [28.63%], followed by diabetes mellitus [27.2%] and ischemic heart diseases [7.27%]. 63.6% of elderly had minimal disability, 12.3% had moderate disability, 2.7% were severely disabled and 21.4% had no disability. Most of elderly patient admitted to CHK for C.V.A [13.6] Most common disorder were related to Digestive System 28.6%, among Co-Morbidities [Chronic] Hypertension was frequent 28.63%. A large number [78.6%] of elderly patient had some sort of disabilities